Maintaining the initial clinical response after ketamine in bipolar and unipolar depression: an important next-step challenge.
نویسنده
چکیده
منابع مشابه
Ketamine for treatment-resistant depression: recent developments and clinical applications.
Approximately one-third of patients with major depressive disorder (MDD) do not respond to existing antidepressants, and those who do generally take weeks to months to achieve a significant effect. There is a clear unmet need for rapidly acting and more efficacious treatments. We will review recent developments in the study of ketamine, an old anaesthetic agent which has shown significant promi...
متن کاملA systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes.
BACKGROUND There is growing interest in glutamatergic agents in depression, particularly ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. We aimed to assess the efficacy of ketamine in major depressive episodes. METHOD We searched EMBASE, PsycINFO, CENTRAL, and Medline from 1962 to January 2014 to identify double-blind, randomized controlled trials with allocation concea...
متن کاملKetamine for treatment-resistant unipolar depression: current evidence.
Currently available drugs for unipolar major depressive disorder (MDD), which target monoaminergic systems, have a delayed onset of action and significant limitations in efficacy. Antidepressants with primary pharmacological targets outside the monoamine system may offer the potential for more rapid activity with improved therapeutic benefit. The glutamate system has been scrutinized as a targe...
متن کاملPlasma brain-derived neurotrophic factor in bipolar and unipolar depression
Objective There is increasing evidence that BrainDerived Neurotrophic Factor may be involved in the pathophysiology of depression and the actions of antidepressants. At the same time, the differential diagnosis between unipolar and bipolar depression is often a challenge with important treatment implications. The aim of the present study was to analyze the relationship between BrainDerived Neur...
متن کاملAntidepressant, mood stabilizing and procognitive effects of very low dose sublingual ketamine in refractory unipolar and bipolar depression.
Intravenous ketamine (0.5 mg/kg) produces robust, rapid and long-lasting antidepressant effects, but is unpractical. Sublingual administration of ketamine renders better bioavailability (~30%) and less conversion to norketamine than oral administration. We evaluated the therapeutic effects and tolerability of very low dose sublingual (VLDS) racemic ketamine (10 mg from a 100 mg/ml solution for ...
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عنوان ژورنال:
- The Journal of clinical psychiatry
دوره 76 6 شماره
صفحات -
تاریخ انتشار 2015